I've just completed a book, published 1st July, with all images scanned on a Nikon Coolscan and printed at 300ppi and I am very satisfied with the results. In my opinion not only do they look different to digital, but the tonality, shadow detail and colours are actually more convincing.

One of the benefits of film is you can always get a better scan done when you need top quality (you don't need to get an expensive scanner straight away), and you have all the digital workflow and tools available.

Go for it!