I scan 135 negatives using a prosumer scanner (Nikon Coolscan V) and have compared a couple of my image scans printed at 12x8 by Peak Imaging with prints supplied by Peak from the negative (i.e. via their megabucks scanner). There is a small difference, but you've got to have a really sharp shot (50mm prime f/8 territory) and squint until your eyes hurt to see it. Page 13 in April 5th AP is one of my home scans reproduced at full-page and it seems fine to me. Any bigger and I'd get someone like Peak to scan it. Basically I'm quite happy with home scanning at the moment.